Phytochemical and Anti coagulant Activity of Mahogany (Swietenia macrophylla) King Fruit Extract on Rat Blood

Adel Grace P. Gaudicos, Edgardo E. Tulin


The study was conducted to investigate the anticoagulant property of mahogany Swietenia macrophylla king fruit extracts using its pulp and seeds. Extracts were evaluated for its anticoagulant effect on rat blood using blood clotting time. Blood was tested with different seed extracts; ethanol, hexane, and water with 20%, 40%, 60%, and 80% concentrations. Study revealed that ethanolic seed and pulp extracts increased the clotting time significantly at 80% concentration which confirmed the use of Swietenia macrophylla in arresting stroke or high blood pressure traditionally.


blood thinner;coagulation;blood clot


Arts, I. C. W. & Hollman, P. C. H. (2005). Polyphenols and disease risk in epidemiologic studies. American Journal ofClinicalNutrition,81,317-325.

Balijepalli, M. K., Suppaiah V., Chin A., Buru A.S., Sagineedu S.R., Pichika

M.R. (2015). Acute oral toxicity studies of Swietenia macrophylla seeds in sprague dawley rats. Journal of Pharmacognosy Research,7(1),38-44.

Environmental Enrichment for Laboratory Rodents (2005). Institute for Laboratory Animal Academic Research Journal, 46(2),148-161.

Fisher, N. D. L., & Hollenberg, N. K. (2005). Flavonoids for cardiovascular health: the science behind sweetness. Journal of Hypertension,23,1453-1459.

Geetha, S, Surash R.,Sreenivasan S.,Mohd. N.M.„ Sabariah I.,and M.M Sharif ( 2010). Brine shrimp lethality and acute oral toxicity studies on Sweitenia mahogani (linn) Jacq. seed methanolic extract. Journal of Pharmacognosy Research, 2(4),215-220.

Guevarra, B. G., & Recio, B. V. (2005). A guidebook to plant screening : phytochemical and biological. Manila: University of Santo Tomas Publishing House.

Huang, E. S, Strate L.L, Ho W.W, Lee S.S, Chan A.T. (2011). Long term use of aspirin and the risk of gastrointestinal bleeding. American Journal of Medicine, 124: 426-433.

Lister, E., & Wilson, P. (2001). Measurement of total phenolics and abts assay for antioxidant activity. New Zealand: Crop ResearchInstitute

Marieb, E., & Haelin, K., (2010). Human anatomy and physiology (8th ed.). New York: Pearson

Naveen, Y. P., Divya, R. G., Ahmed, F., & Urooj, A. (2014). Pharmacological Effects and Active Phytoconstituents of Swietenia mahogany: A review. Journal ofIntegrativeMedicine,12(2): 86-93.

National Research Council. (2010). National Research Council Committee for the Update on the Guide for the Care and Use of Laboratory Animals (8th ed.). Washington D.C.: National Academic Press.

Ochei, J., & Kolhatkar, K. (2000). Medical laboratory science: Theory and practice (2nd edition). New Delhi: Tata Mcgraw HillPublishingCompany.

Rao, A. V., & Gurfinkel, D. M. (2000). The bioactivity of saponins: triterpenoid and steroidalglycosides. Drug Metabolism and Drug interactions Journal,17,211-235.

Spanos, G. A., & Wrolstad, R. E. (1990). Influence of processing and storage on the phenolic composition of Thompson seedless grape juice. Journal of Agriculture and Food Chemistry, 38, 1565-1571.

Sparg, S. G., Light, M. E., Standen, J. V. (2004). Biological activities and distribution of plant saponins. Journal of Ethnopharmacology,94(2-3),219-243.

Vita, J. A. (2005). Polyphenols and cardiovascular disease: effects on endothelial and platelet function. American Journal of Clinical Nutrition, 81,292S-297S.

Waddington, E., Puddey, I. B., & Croft, K. D. (2004). Red wine polyphenolic compounds inhibit atherosclerosis in apolipoprotein E-deficient mice independent of effects on lipid peroxidation. American Journal of ClinicalNutrition,79,54-61.

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